Understanding the complex pathophysiology of Alzheimer’s disease is greatly needed in order to develop enhanced treatments that will improve symptoms and quality of life. Recently, the gut has received attention because intestinal dysbiosis appears to play a key role in the pathological process of Alzheimer’s disease. Newer research also points to CBD due to its anti-inflammatory and neuroprotective properties in the gut. What exactly is the connection between Alzheimer’s, the gut and CBD?
The Microbiota-Gut-Brain Axis
The key to understanding the connection to the gut and how it influences the development of Alzheimer’s is found in the microbiota-gut-brain axis. Within this axis, gut microbiota appear to regulate functional integrity of the intestine through interactions with the endocannabinoid system, immunological status and brain functions. When intestinal dysbiosis is present, meaning significant alterations in gut microbiota, it can aggravate or generate the pathological progress of Alzheimer’s disease and other neurodegenerative disorders.
A Bit More on Intestinal Dysbiosis
Some experts believe that most human diseases and disorders begin in the gut. This is the case with intestinal dysbiosis and Alzheimer’s disease. Pathological and/or metabolic changes in the gut reach the central nervous system which leads to neuroinflammation, cell death and Alzheimer’s disease, which in turn leads to cognitive decline and behavioral disturbances. The microbiota-gut-brain axis is the main entrance-route of microbial products leaking into the central nervous system. Individuals with Alzheimer’s tend to have intestinal dysbiosis.
The Role of CBD
Recently, a good number of studies have demonstrated positive results and potent effects of cannabidiol or CBD. It is known to have neuroprotective and anti-inflammatory properties and may be able to control intestinal bacteria populations. This may be helpful in cooling down systemic inflammation which compromises permeability of the blood-brain-barrier, causing neuroinflammation and eventual cell death, all implicated in the development of Alzheimer’s disease.
Final Thoughts on Alzheimer’s Disease, The Gut and CBD
Millions of people live with the deteriorative effects of Alzheimer’s disease in the United States and millions more around the world. To date, there is no treatment that prevents or slows the process significantly. Recently, the microbiota-gut-axis and intestinal dysbiosis have shed light on a complex series of biological events that ties the gut directly to the formation of Alzheimer’s. Since CBD has demonstrated anti-inflammatory and neuroprotective properties, and improves cognition in experimental models, it is hoped to become a major therapeutic for the prevention and treatment of Alzheimer’s disease in the near future.